Merkezi Sinir Sistemi Tümörleri/WHO Sınıflaması

WHO Sınıflaması

1. Neuroepithelial Tumors

• Astrocytic Tumors
  • Pilocytic astrocytoma 9421/1
    • Pilomyxoid astrocytoma 9425/3
  • Subependymal giant cell astrocytoma 9384/1
  • Pleomorphic xanthoastrocytoma 9424/3
  • Diffuse astrocytoma 9400/3
    • Fibrillary astrocytoma 9420/3
    • Protoplasmic astrocytoma 9410/3
    • Gemistocytic astrocytoma 9411/3
  • Anaplastic astrocytoma 9401/3
  • Glioblastoma 9440/3
    • Giant cell glioblastoma 9441/3
    • Gliosarcoma 9442/3
  • Gliomatosis cerebri 9381/3
• Oligodendroglial tumours
  • Oligodendroglioma 9450/3
  • Anaplastic oligodendroglioma 9451/3
• Oligoastrocytic tumours
  • Oligoastrocytoma 9382/3
  • Anaplastic oligoastrocytoma 9382/3
• Ependymal tumours
  • Subependymoma (WHO Grade 1) 9383/1
  • Myxopapillary ependymoma (WHO Grade 1) 9394/1
  • Ependymoma (WHO Grade 2) 9391/3
    • Cellular 9391/3
    • Papillary 9393/3
    • Clear cell 9391/3
    • Tanycytic 9391/3
  • Anaplastic ependymoma(WHO Grade 3) 9392/3
• Choroid plexus tumours
  • Choroid plexus papilloma 9390/0
  • Atypical choroid plexus papilloma 9390/1*
  • Choroid plexus carcinoma 9390/3
• Other neuroepithelial tumours
  • Astroblastoma 9430/3
  • Chordoid glioma of the third ventricle 9444/1
  • Angiocentric glioma 9431/1*
• Neuronal and mixed neuronal-glial tumours
  • Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos) 9493/0
  • Desmoplastic infantile astrocytoma/ganglioglioma 9412/1
  • Dysembryoplastic neuroepithelial tumour 9413/0
  • Gangliocytoma 9492/0
  • Ganglioglioma 9505/1
  • Anaplastic ganglioglioma 9505/3
  • Papillary glioneuronal tumor 9509/1*
  • Rosette-forming glioneuronal tumour of the fourth ventricle 9509/1*
  • Central neurocytoma 9506/1
  • Extraventricular neurocytoma 9506/1*
  • Cerebellar liponeurocytoma 9506/1*
  • Paraganglioma of the filum terminale 8680/1

2. Tumours of the pineal region

• Pineocytoma 9361/1
• Pineal parenchymal tumour of intermediate differentiation 9362/3
• Pineoblastoma 9362/3
• Papillary tumour of the pineal region 9395/3*

3. Embryonal tumours

• Medulloblastoma 9470/3
  • Desmoplastic/nodular medulloblastoma 9471/3
  • Medulloblastoma with extensive nodularity 9471/3*
  • Anaplastic medulloblastoma 9474/3*
  • Large cell medulloblastoma 9474/3
• CNS primitive neuroectodermal tumours (PNETs)
• CNS PNET, NOS 9473/3
  • CNS neuroblastoma 9500/3
  • CNS ganglioneuroblastoma 9490/3
  • Medulloepithelioma 9501/3
  • Ependymoblastoma 9392/3
• Atypical teratoid / rhabdoid tumour 9508/3

4. Tumors of the Cranial and Paraspinal Nerves

• Schwannoma (Neurilemoma, neurinoma) 9560/0
  • Cellular 9560/0
  • Plexiform 9560/0
  • Melanotic 9560/0
• Neurofibroma 9540/0
  • Plexiform 9550/0
• Perineurioma 9571/0
  • Intraneural perineurioma 9571/0
  • Soft tissue perineurioma 9571/0
• Malignant peripheral nerve sheath tumour (MPNST) 9540/3
  • Epithelioid 9540/3
  • MPNST with divergent mesenchymal and / or epithelial differentiation 9540/3
  • Melanotic 9540/3

5. Tumors of the Meninges

• Tumours of meningothelial cells
  • Meningioma 9530/0
• Mesenchymal tumours
  • Lipoma 8850/0
  • Angiolipoma 8861/0
  • Hibernoma 8880/0
  • Liposarcoma (intracranial) 8850/3
  • Solitary fibrous tumour 8815/0
  • Fibrosarcoma 8810/3
  • Malignant fibrous histiocytoma 8830/3
  • Leiomyoma 8890/0
  • Leiomyosarcoma 8890/3
  • Rhabdomyoma 8900/0
  • Rhabdomyosarcoma 8900/3
  • Chondroma 9220/0
  • Chondrosarcoma 9220/3
  • Osteoma 9180/0
  • Osteosarcoma 9180/3
  • Osteochondroma 9210/0
  • Haemangioma 9120/0
  • Epithelioid haemangioendothelioma 9133/1
  • Haemangiopericytoma 9150/1
  • Angiosarcoma 9120/3
  • Kaposi sarcoma 9140/3
• Primary melanocytic lesions
  • Diffuse melanocytosis 8728/0
  • Melanocytoma 8728/1
  • Malignant melanoma 8720/3
  • Meningeal melanomatosis 8728/3
• Other neoplasms related to the meninges
  • Haemangioblastoma 9161/1

6. Lymphomas and Hematopoietic Neoplasms

• Malignant lymphomas 9590/3
• Plasmacytoma 9731/3
• Granulocytic sarcoma 9930/3

7. Germ Cell Tumors

• Germinoma 9064/3
• Embryonal carcinoma 9070/3
• Yolk sac tumour 9071/3
• Choriocarcinoma 9100/3
• Teratoma 9080/1
  • Mature 9080/0
  • Immature 9080/3
  • Teratoma with malignant transformation 9084/3
• Mixed germ cell tumours 9085/3

8. Tumors of the Sellar Region

• Craniopharyngioma 9350/1
  • Adamantinomatous 9351/1
  • Papillary 9352/1
• Granular cell tumour 9582/0
• Pituicytoma 9432/1*
• Spindle cell oncocytoma of the adenohypophysis 8291/0*

9. Metastatic Tumors